In Deus Ex, the gamer plays the role of J.C. Denton, a rookie anti-terrorist agent with UNATCO -- the UN Anti-Terrorist Coalition. J.C., a nano-technologically augmented operative with remarkable abilities, has been ordered to investigate the terrorist activity in and around New York concerning a plague called the Gray Death. The elusive plague has no known cure and the only temporary treatment is Ambrosia, which is in drastically short supply. J.C. must make sure that the terrorists do not divert supplies of Ambrosia from the people who truly need it. But as J.C. encounters the terrorists, he begins to notice certain discrepancies, and eventually questions the nature of his orders. Ultimately, J.C. ends up distrusting UNATCO and is caught in the middle of mind-bending plot as various groups vie for control of the world. In discovering the facts, J.C. learns that in this world you can trust no one, as your enemies, and even your allies, may be more than they appear.

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